PAMAQUINE NAPHTHOATE AS A PROPHYLACTIC FOR MALARIAL INFECTIONS 1
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چکیده
منابع مشابه
Pamaquine Naphthoate as a Prophylactic for Malarial Infections.
Plasmoquine, 6-methoxy-8( 1-methyl-4-diethylamino)butyl-aminoquinoline, has been assigned the name "Pamaquine" by the United States Pharmacopea XII, and will be so referred to in this presentation. This anti-malarial has been so frequently discussed in the literature that a detailed review of its history will not be included here. Reference will be made only to those papers which bear directly ...
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In the mol-ecular structure of the title compound, C(12)H(9)BrO(2), the methoxy-carbonyl group is twisted by a dihedral angle of 29.8 (3)°with respect to the naphthalene ring system. An overlapped arrangement is observed between parallel naphthalene ring systems of adjacent mol-ecules, and the face-to-face distance of 3.590 (9) Å suggests there is π-π stacking in the crystal structure.
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It is needless to describe the chemical nature of the drug here and the literature on the subject of the treatment of malaria by the use of plasmochin is now too extensive to refer to in detail. The observations made by others may be summarised as follows :? (1) It has a destructive action on the trophozoites of P. vivax and P. malarice. (2) It has no such action on the trophozoites of P. falci...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1947
ISSN: 0021-9738
DOI: 10.1172/jci101792